Although antihistamines are by no means a recent discovery, the development of the new class of non-sedating antihistamines allows many more allergy sufferers to benefit from the therapeutic effects of the drugs without experiencing their annoying and often unmanageable side effects such as sedation, which is a condition or state in which one feels overly calm and serene; it is akin to being tranquillized.
For years, the cost of relief for these people was feeling groggy and out of sorts for hours.
These Drugs combat the histamine released during an allergic reaction, by blocking the action of the histamine on the tissue.
Histamine is a substance produced by the body as part of its natural defense.
Histamine is responsible for the immune response to the stimuli that we are familiar in symptoms as itching, sneezing, hives, runny nose and watery eyes. Traditional antihistamines act by minimizing swelling and controlling the dilation of small blood vessels that translate to those common allergy symptoms.
They accomplished this by blocking the histamine from connecting with its receptors in specific nerve, muscle and glandular types of cells.
There are some others as well that play a less significant role.
Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are used to treat the symptoms of an allergic reaction, such as edema (swelling), itch, inflammation (redness), sneezing, or a runny nose or watery eyes.
The released histamine binds to its receptors (H–1 receptors) causing a chain reaction that includes an increase in blood flow to the area and the release of other chemicals that add to the allergic response. Antihistamines do not stop the formation of histamine nor do they stop the conflict between the Immunoglobulin (Ig E) and antigen.Sedation methods in dentistry include inhalation sedation (using nitrous oxide), oral sedation, and intravenous (IV) sedation.Inhalation sedation is also sometimes referred to as relative analgesia.Newer 'non sedating' antihistamines are generally thought to be somewhat less effective.When the body comes into contact with something to which it is allergic, whether through contact, respiration or consumption, substances called histamines are released to attack the allergen.